CAS No.: | 2381089-83-2 |
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Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
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Product Name | Retatrutide |
CAS NO. | 2381089-83-2 |
Other name | LY3437943 GIPR/GLP-1R |
Appearance | White freeze dry Powder |
Purity | 99.88%min. HPLC |
Application | Drug peptides |
Shelf Life | 24Months |
Storage | Store at a temperature of 2-8 oC, protected from light |
Retatrutide is a 39 amino acid single peptide with triple agonist activity at the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). The backbone is conjugated to a C20 fatty diacid moiety at position 17.
Retatrutide has a Glucose-dependent insullinotropic polypeptide (GIP) peptide backbone, which then contains three non-coded amino accids. Aib2 (α-amino isobutyyric accid) residues at positions 2 and 20 provide stability against Dipeptidyl Peptidase 4 (DPP4) cleavage and contribute to GIP activity. αMeL13 (α-methyl-L-leucine)at position 20 also contributes to GIP and glucagon activity.
Description |
Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). |
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Clinical Trial |
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Molecular Weight |
4731.33 (free base) |
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Formula |
C221H342N46O68.xC2HF3O2 |
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Appearance |
Solid |
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Color |
White to off-white |
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Sequence |
Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
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SMILES |
[LY3437943 (TFA salt)] |
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Shipping |
Room temperature in continental US; may vary elsewhere. |
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Storage |
Sealed storage, away from moisture
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