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• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Crude
• Colour: White
• Specification: g
• Trademark: Qingye
• Origin: China
• HS Code: 000000
• Production Capacity: 50000kg

Product Description

Product Name: Retatrutide
CAS: 1415456-99-3
MF: C187H291N45O59
Water Solubility: Soluble to 0.70 mg/ml in water
Storage Temp: Keep in dark place,Sealed in dry,Store in freezer,under                          -20°C
Product Specification: 2mg/5mg/10mg
Form: Solid
Color: White

CagriSema injection is a combination therapy that includes the glucagon-like peptide-1 (GL-1) receptor agonist sema and the long-acting amylin analog cagrilintide . The therapy has weight loss benefits, but the effect on glycated hemoglobin (HbA1c) is unclear.


The 83rd American Diabetes Association Scientific Conference 2023 (ADA 2023) will be held in San Diego, USA on June 23, local time. A study was announced during the meeting, which evaluated the effectiveness and safety of CagriSema (sema combined with canaglitide) in patients with type 2 diabetes. Results showed that in patients with type 2 diabetes, treatment with CagriSema improved glycemic control and resulted in significant weight loss compared with sema or canaglitide monotherapy and was well tolerated with no new safety concerns. sexual signals.

This multi-center, double-blind, phase 2 trial included a total of 92 patients with a body mass index (BMI) ≥27 kg/m2 from 17 research centers in the United States from August 2 to October 18, 2021, who received metformin with or without metformin. Adult patients with type 2 diabetes (HbA1c 7.5%~10.0%) treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors were randomly assigned in a 1:1:1 ratio to receive a weekly subcutaneous injection of CagriSema ( n=31), sema (n=31), or canaglitide (n=30) (dose escalation to 2.4 mg over 16 weeks) for 32 weeks. Of these patients, 59 (64%) were male. The average age of patients was 58 years old. The primary endpoint of the study was the change in HbA1c from baseline. Secondary endpoints were body weight, fasting glucose, continuous glucose monitoring (CGM) parameters and safety.

Q1:What's your Moq?
A:It depends on different products,we can accept sample order.

Q2:How about delivery leadtime?
A:Delivery lead time: About 1-2 days after payment confirmed. (Chinese holiday not included)

Q3: Is there a discount?
A:Different quantity has different discount.

Q4:How to start orders or make payments?
A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Bitcoin.

Q5: How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6. We don't know you at all, how can we trust you?
A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.

Q7.Do you test all your goods before delivery?
A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.
 

CERTIFICATE OF ANALYSIS

Product Name	Sema  Retatrutide	Sample Source		Workshop 106
Batch Number	LX106S2305107	Packing Size		131.03g/bag, 401.6g/bag, 477.57g/bag
Quantity	1010.2g	Manufacturing Date		Apr-10-2023
Number of Packages	3	Retest Date		Apr-09-2025
Sample Date	Apr-28-2023	Report Date		May-08-2023
Testing Reference	QC-03-1003-02, QC-02-1595-03
TEST ITEM	SPECIFICATION		TEST RESULT
Appearance	White or almost white loose powder		white loose powder
Solubility	Freely soluble in water, soluble in DMF at 1 mg/mL, 30 mg/mL in DMSO, 0.2 mg/ml in a 1:4 solution of DMSO:PBS		conforms
Identification (MS)	4111.12±0.5Da		4111.15
Identification (HPLC)	Examine the chromatograms obtained in the assay. The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution.		conforms
Specific Optical Rotation [α]^20D (anhydrous substance)	-6.0° to -16.0°		-10.3°
Purity (HPLC)	NLT 98.0%		99.47%
Water Content	NMT 8.0%		3.9%
pH	7.0 to 9.0		7.9
Solution Clarity and Color	Clear and colorless		conforms
Acid Group Ions	Trifluoroacetate ion NMT 0.1%		N.D.
	Phosphate ion NMT 0.1%		N.D.
	Chloride ion NMT 0.1%		0.003%
	Acetate ion NMT 0.1%		N.D.
Sodium Ion	NMT 4.0%		2.1%
Related Substances I	SPEC054-Z18 NMT 0.50%		N.D.
	SPEC054-Z20 NMT 0.30%		0.03%
	SPEC054-Z21 NMT 0.50%		N.D.
	SPEC054-Z57 NMT 0.20%		N.D.
	Any other impurities NMT 0.10%		0.02%
	Total impurities NMT 1.0%		0.08%
Related Substances II	SPEC054-Z19 NMT 0.30%		0.02%
	SPEC054-Z23 NMT 0.20%		0.03%
	SPEC054-Z69 NMT 0.20%		N.D.
	Total related substances I and II NMT 1.50%		0.12%
Amino Acid Analysis	Asp:0.8-1.2		1.1
	His:0.8-1.2		1.0
	Tyr: 0.8-1.2		1.2
	Lys: 0.8-1.2		1.0
	Ile: 0.8-1.2		1.0
	Aib: 0.8-1.2		0.8
	Leu: 1.6-2.4		2.2
	Val: 1.6-2.4		2.1
	Arg: 1.6-2.4		2.0
	Thr: 1.6-2.4		1.9
	Phe: 1.6-2.4		1.9
	AEEA: 1.6-2.4		1.7
	Ser: 2.4-3.6		2.8
	Ala: 2.4-3.6		3.0
	Gly: 3.2-4.8		4.0
	Glu: 4.0-6.0		5.2
	Trp (Partially destroyed during acid hydrolysis)		detected
Bacterial Endotoxins	2 EU/mg		< 2 EU/mg
Microbial Limits	Total aerobic microbial count NMT 100 cfu/g		< 10 cfu/g
	Total yeasts and molds count NMT 50 cfu/g		< 10 cfu/g
	Escherichia coli count		Absent in 1g
Conclusion: This batch of product COMPLIES with the prescribed standards.
Storage condition: -20°C ± 5°C, well-closed containers, protected from light.

Related Products

GENERIC PEPTIDES (GMP)

#	Product	Sequence	Therapeutic Area	Form	Unit Size
4109712	Semaglutid CAS No.: 1415456-99-3	H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH	Type II diabetes mellitus Obesity	Lyophilized powder	2 mg/vial 5 mg/vial 10 mg/vial 15 mg/vial 20 mg/vial 1 g/tube
4109713	Tirzepatid CAS No.: 1415456-99-3	H-Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{diacid-gamma-Glu-(AEEA)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2	Type II diabetes mellitus Obesity	Lyophilized powder	10 mg/vial 15 mg/vial 20 mg/vial 30 mg/vial 60 mg/vial 1 g/tube
4109714	Cagrilintide CAS No.: 1415456-99-3	{Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH2	Type II diabetes mellitus Obesity	Lyophilized powder	5 mg/vial 10 mg/vial 1 g/tube
4109715	CagriSema	Blend	Type II diabetes mellitus Obesity	Lyophilized powder	5 mg/vial 10 mg/vial 20 mg/vial 1 g/tube
4109716	Retatrutide CAS No. 2381089-83-2	Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2	Treatment of type 2 diabetes Treatment of obesity	Lyophilized powder	8 mg 10 mg 12 mg 15 mg 1 g/tube

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